The effects of prostaglandins E1, E2, F1α and F2α on guinea-pig ileal and colonic peristalsis
- 1 September 1977
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 29 (1), 276-280
- https://doi.org/10.1111/j.2042-7158.1977.tb11311.x
Abstract
Prostaglandins (PGE1, E2, F1α and F2α) have been tested on the peristaltic reflex in isolated segments of guinea-pig ileum and colon using simultaneous recordings of fluid propulsion and longitudinal and circular muscle activity. Propulsion and circular muscle peristaltic activity were increased by serosally applied PGF compounds in the ileum and PGE or PGF compounds in the colon following initial contraction of the longitudinal muscle. This is consistent with a role for prostaglandins in peristalsis. Mucosally applied PGF compounds had no significant effect.Keywords
This publication has 6 references indexed in Scilit:
- THE EFFECTS OF PROSTAGLANDINS ON GUINEA‐PIG ISOLATED INTESTINE AND THEIR POSSIBLE CONTRIBUTION TO MUSCLE ACTIVITY AND TONEBritish Journal of Pharmacology, 1975
- THE EFFECT OF INDOMETHACIN ON THE RELEASE OF PROSTAGLANDIN E2 AND ACETYLCHOLINE FROM GUINEA-PIG ISOLATED ILEUM AT REST AND DURING FIELD STIMULATIONBritish Journal of Pharmacology, 1974
- Studies on prostaglandin antagonistsBritish Journal of Pharmacology, 1971
- Absorption and metabolism of prostaglandin e1 by perfused rat jejunum in vitroBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969
- Effect of prostaglandins E1 and E2 on intestinal motility in the guinea‐pig and ratBritish Journal of Pharmacology, 1968
- Effects of prostaglandins E1 and E2 on human, guinea‐pig and rat isolated small intestineBritish Journal of Pharmacology, 1968