Evolutionary and Somatic Selection of the Antibody Repertoire in the Mouse
- 20 November 1987
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 238 (4830), 1088-1094
- https://doi.org/10.1126/science.3317826
Abstract
The repertoire of antibody variable (V) regions has been subject to evolutionary selection, affecting both the diversity of V region genes in the germline and their expression in the B lymphocyte population and its subsets. In ontogeny, contact with an antigen leads to the expansion of B cells expressing antibodies complementary to it. In a defined phase of B cell differentiation, new sets of V regions are generated from the existing repertoire through somatic hypermutation. Cells carrying advantageous antibody mutants are selected into the memory compartment and produce a stable secondary response upon reexposure to the antigen.Keywords
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