CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke
- 17 November 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Metabolic Brain Disease
- Vol. 26 (1), 87-90
- https://doi.org/10.1007/s11011-010-9226-6
Abstract
Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25+Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3(DTR) mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.Keywords
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