Highly enantioselective addition of ketones to nitroolefins catalyzed by new thiourea–amine bifunctional organocatalysts
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- 1 January 2006
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 13,p. 1451-1453
- https://doi.org/10.1039/b517937h
Abstract
A new and effective organocatalytic system: primary amine derived chiral thiourea catalyst 4a and AcOH–H2O additive, which converts different ketones to γ-nitroketones in high yields (82–99%) and enantioselectivities (90–99%) has been described.Keywords
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