Morbidity and mortality of patients diagnosed with systemic sclerosis after the age of 75: a nested case-control study
- 25 January 2006
- journal article
- Published by Springer Science and Business Media LLC in Clinical Rheumatology
- Vol. 25 (6), 831-834
- https://doi.org/10.1007/s10067-005-0177-y
Abstract
This study aims to characterize the clinical features of a cohort of patients diagnosed with systemic sclerosis (SSc) after the age of 75 and compare them to a group diagnosed at a younger age. We record the review of 769 patients diagnosed with SSc over the past 16 years. Utilizing a nested case-control model, we compare demographics, disease severity, morbidity, and mortality data of all patients diagnosed after the age of 75 to sex- and disease-type-matched, randomly selected group of patients diagnosed with SSc before the age of 60. Twelve patients were diagnosed with SSc after the age of 75, seven with the diffuse, and five with the limited form. It took longer to diagnose SSc in the older patients, and comparison of disease severity revealed a worse pulmonary picture and a more frequent development of malignancy in the older patients as compared with the younger ones. During a mean follow-up of 36.2 months, our cohort of patients did not have worsening in their disease severity, though 6 months after the last follow-up, six patients died. We conclude that a diagnosis of SSc at an older age appears to be a poor prognostic indicator related to both disease severity and comorbidities. A higher clinical suspicion will lead to an earlier diagnosis and a potential decrease in morbidity and mortality.Keywords
This publication has 11 references indexed in Scilit:
- Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis.2004
- Following the Molecular Pathways toward an Understanding of the Pathogenesis of Systemic SclerosisAnnals of Internal Medicine, 2004
- A disease severity scale for systemic sclerosis: development and testing.1999
- Racial differences in scleroderma among women in MichiganArthritis & Rheumatism, 1997
- Systemic sclerosis in the elderlyClinical Rheumatology, 1992
- Preliminary criteria for the classification of systemic sclerosis (scleroderma)Arthritis & Rheumatism, 1980
- Progressive systemic sclerosis in the elderlyPublished by Oxford University Press (OUP) ,1979
- Epidemiology of Systemic Sclerosis (Scleroderma)Annals of Internal Medicine, 1971
- SCLERODERMA IN THE ELDERLY, WITH SPECIAL REFERENCE TO THE CRST SYNDROMEJournal of the American Geriatrics Society, 1971
- Systemic SclerodermaArchives of Dermatology, 1961