Antineoplastic Agents. 573. Isolation and Structure of Papilistatin from the Papilionid Butterfly Byasa polyeuctes termessa
- 19 January 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 73 (2), 164-166
- https://doi.org/10.1021/np9004689
Abstract
Bioassay-guided separation of an extract of the wings from a Taiwan butterfly, Byasa polyeuctes termessa, allowed isolation of a new cancer cell growth inhibitor designated papilistatin (1a). The structure was determined by analysis of 1D and 2D NMR spectra and by HRMS. Against a panel of six human and the murine P388 leukemia cancer cell lines, papilistatin exhibited cancer cell growth inhibition with GI50’s of 0.093−3.5 μg/mL. Papilistatin was also found to have antibacterial activity.Keywords
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