Negative regulation of the anti‐human immunodeficiency virus and chemotactic activity of human stromal cell‐derived factor 1α by CD26/dipeptidyl peptidase IV
- 17 July 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 431 (2), 236-240
- https://doi.org/10.1016/s0014-5793(98)00763-7
Abstract
Stromal cell-derived factor 1α (SDF-1α) is a chemokine that has been shown to prevent infection of T-tropic HIV strains and is a possible substrate of CD26/dipeptidyl peptidase IV (DPPIV). In this study, we show that SDF-1α was cleaved at the N-terminal region by CD26/DPPIV and as a result the inhibitory activity of SDF-1α against HIV infection disappeared. Moreover, the chemotactic activity of SDF-1α also disappeared specifically by DPPIV activity of recombinant soluble CD26. These results suggested that dissemination of T-tropic HIV strains in vivo may be facilitated by CD26/DPPIV via inactivation of functional SDF-1αKeywords
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