New, chiral silylated organophosphorus(III) reagents: syntheses and applications in the asymmetric phosphorylation of aldehydes

Abstract

The new silylated organophosphorus(III) compounds, (1R,2S)-(O,N-ephedrine)POSiR₃(R₃= Ph₃, Bu^tMe₂, Et₃) have been synthesised and shown to react with benzaldehyde to afford the phosphonate esters (1R,2S)-(O,N-ephedrine)P(O)CHPh(OSiR₃) with good stereoselectivity.