Fluorescent biomarkers demonstrate prospects for spreadable vaccines to control disease transmission in wild bats
- 1 December 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Ecology & Evolution
- Vol. 3 (12), 1697-1704
- https://doi.org/10.1038/s41559-019-1032-x
Abstract
Vaccines that autonomously transfer among individuals have been proposed as a strategy to control infectious diseases within inaccessible wildlife populations. However, rates of vaccine spread and epidemiological efficacy in real-world systems remain elusive. Here, we investigate whether topical vaccines that transfer among individuals through social contacts can control vampire bat rabies-a medically and economically important zoonosis in Latin America. Field experiments in three Peruvian bat colonies, which used fluorescent biomarkers as a proxy for the bat-to-bat transfer and ingestion of an oral vaccine, revealed that vaccine transfer would increase population-level immunity up to 2.6 times beyond the same effort using conventional, non-spreadable vaccines. Mathematical models showed that observed levels of vaccine transfer would reduce the probability, size and duration of rabies outbreaks, even at low but realistically achievable levels of vaccine application. Models further predicted that existing vaccines provide substantial advantages over culling bats-the policy currently implemented in North, Central and South America. Linking field studies with biomarkers to mathematical models can inform how spreadable vaccines may combat pathogens of health and conservation concern before costly investments in vaccine design and testing.Funding Information
- U.S. Department of Health & Human Services | National Institutes of Health (F32AI134016, U01GM110712)
- Royal Society (CH160097, CH160097, CH160097, CH160097)
- Wellcome Trust (102507/Z/13/Z)
This publication has 50 references indexed in Scilit:
- A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challengeVaccine, 2011
- Urban habituation, ecological connectivity and epidemic dampening: the emergence of Hendra virus from flying foxes (Pteropusspp.)Proceedings Of The Royal Society B-Biological Sciences, 2011
- Oral Rabies Vaccination in North America: Opportunities, Complexities, and ChallengesPLoS Neglected Tropical Diseases, 2009
- Transmission Dynamics and Prospects for the Elimination of Canine RabiesPLoS Biology, 2009
- Contact heterogeneity in deer mice: implications for Sin Nombre virus transmissionProceedings Of The Royal Society B-Biological Sciences, 2009
- Vaccinating the vampire bat Desmodus rotundus against rabiesVirus Research, 2008
- Temporal Dynamics of European Bat Lyssavirus Type 1 and Survival of Myotis myotis Bats in Natural ColoniesPLOS ONE, 2007
- Harvesting can increase severity of wildlife disease epidemicsProceedings Of The Royal Society B-Biological Sciences, 2006
- Overview of rabies in the AmericasVirus Research, 2005
- Effects of Vampire Bat Control on Bovine Milk ProductionThe Journal of Wildlife Management, 1977