Impaired glucose metabolism in patients with diabetes, prediabetes, and obesity is associated with severe COVID‐19
Open Access
- 26 June 2020
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 93 (1), 409-415
- https://doi.org/10.1002/jmv.26227
Abstract
Background Identification of risk factors of severe Covid‐19 is critical for improving therapies and understanding SARS‐CoV‐2 pathogenesis. Methods We analyzed 184 patients hospitalized for Covid‐19 in Livingston, New Jersey for clinical characteristics associated with severe disease. Results The majority of Covid‐19 patients had diabetes mellitus (DM) (62.0%), Pre‐DM (23.9%) with elevated FBG, or a BMI > 30 with normal HbA1C (4.3%). SARS‐CoV‐2 infection was associated with new and persistent hyperglycemia in 29 patients, including several with normal HbA1C levels. Forty‐four patients required intubation, which occurred significantly more often in patients with DM as compared to non‐diabetics. Conclusions Severe Covid‐19 occurs in the presence of impaired glucose metabolism in patients, including those with DM, PreDM and obesity. Covid‐19 is asociated with elevated FBG and several patients presented with new onset DM or in DKA. The association of dysregulated glucose metabolism and severe Covid‐19 suggests that SARS‐CoV‐2 pathogenesis involves a novel interplay with glucose metabolism. Exploration of pathways by which SARS‐CoV‐2 interacts glucose metabolism is critical for understanding disease pathogenesis and developing therapies.Keywords
This publication has 19 references indexed in Scilit:
- Clinical Characteristics of Coronavirus Disease 2019 in ChinaNew England Journal of Medicine, 2020
- Diabetes and COVID-19Journal of Diabetes, 2020
- Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, ChinaJAMA, 2020
- Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort studyThe Lancet, 2020
- Clinical considerations for patients with diabetes in times of COVID-19 epidemicDiabetes & Metabolic Syndrome: Clinical Research & Reviews, 2020
- Characterization of ACE and ACE2 Expression within Different Organs of the NOD MouseInternational Journal of Molecular Sciences, 2017
- Diagnosis and Classification of Diabetes MellitusDiabetes Care, 2010
- Binding of SARS coronavirus to its receptor damages islets and causes acute diabetesActa Diabetologica, 2009
- Elevated A1C in Adults Without a History of Diabetes in the U.S.Diabetes Care, 2009
- Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARSDiabetic Medicine, 2006