Epidemiology of Asthma in Children and Adults
Top Cited Papers
Open Access
- 18 June 2019
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pediatrics
- Vol. 7, 246
- https://doi.org/10.3389/fped.2019.00246
Abstract
Asthma is a globally significant non-communicable disease with major public health consequences for both children and adults, including high morbidity, and mortality in severe cases. We have summarized the evidence on asthma trends, environmental determinants, and long-term impacts while comparing these epidemiological features across childhood asthma and adult asthma. While asthma incidence and prevalence are higher in children, morbidity, and mortality are higher in adults. Childhood asthma is more common in boys while adult asthma is more common in women, and the reversal of this sex difference in prevalence occurs around puberty suggesting sex hormones may play a role in the etiology of asthma. The global epidemic of asthma that has been observed in both children and adults is still continuing, especially in low to middle income countries, although it has subsided in some developed countries. As a heterogeneous disease, distinct asthma phenotypes, and endotypes need to be adequately characterized to develop more accurate and meaningful definitions for use in research and clinical settings. This may be facilitated by new clustering techniques such as latent class analysis, and computational phenotyping methods are being developed to retrieve information from electronic health records using natural language processing (NLP) algorithms to assist in the early diagnosis of asthma. While some important environmental determinants that trigger asthma are well-established, more work is needed to define the role of environmental exposures in the development of asthma in both children and adults. There is increasing evidence that investigation into possible gene-by-environment and environment-by-environment interactions may help to better uncover the determinants of asthma. Therefore, there is an urgent need to further investigate the interrelationship between environmental and genetic determinants to identify high risk groups and key modifiable exposures. For children, asthma may impair airway development and reduce maximally attained lung function, and these lung function deficits may persist into adulthood without additional progressive loss. Adult asthma may accelerate lung function decline and increase the risk of fixed airflow obstruction, with the effect of early onset asthma being greater than late onset asthma. Therefore, in managing asthma, our focus going forward should be firmly on improving not only short-term symptoms, but also the long-term respiratory and other health outcomes.Keywords
This publication has 179 references indexed in Scilit:
- Impaired innate interferon induction in severe therapy resistant atopic asthmatic childrenMucosal Immunology, 2013
- IgE Sensitization toAspergillus fumigatusIs Associated with Reduced Lung Function in AsthmaAmerican Journal of Respiratory and Critical Care Medicine, 2010
- National prevalence and risk factors for food allergy and relationship to asthma: Results from the National Health and Nutrition Examination Survey 2005-2006Journal of Allergy and Clinical Immunology, 2010
- Management of severe asthma in childrenThe Lancet, 2010
- Effects of improved home heating on asthma in community dwelling children: randomised controlled trialBMJ, 2008
- Effects on patients with asthma of eradicating visible indoor mould: a randomised controlled trialThorax, 2007
- Overweight, Obesity, and Incident AsthmaAmerican Journal of Respiratory and Critical Care Medicine, 2007
- Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxideJournal of Allergy and Clinical Immunology, 2006
- Regular Smoking and Asthma Incidence in AdolescentsAmerican Journal of Respiratory and Critical Care Medicine, 2006
- Exposure to Alternaria alternata in US homes is associated with asthma symptomsJournal of Allergy and Clinical Immunology, 2006