Minimizing risk associated with elderly liver donors by matching to preferred recipients
- 1 December 2007
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Hepatology
- Vol. 46 (6), 1907-1918
- https://doi.org/10.1002/hep.21888
Abstract
Elderly liver donors (ELDs) represent a possible expansion of the donor pool, although there is great reluctance to use ELDs because of reports that increasing donor age predicts graft loss and patient death. The goal of this study was to identify a subgroup of recipients who would be least affected by increased donor age and thus best suited to receive grafts from ELDs. A national registry of deceased donor liver transplants from 2002–2005 was analyzed. ELDs aged 70–92 (n = 1043) were compared with average liver donors (ALDs) aged 18–69 (n = 15,878) and ideal liver donors (ILDs) aged 18–39 (n = 6842). Recipient factors that modified the effect of donor age on outcomes were identified via interaction term analysis. Outcomes in recipient subgroups were compared using Kaplan‐Meier survival analysis. Recipients preferred for ELD transplants were determined to be first‐time recipients over the age of 45 with body mass index P > 0.1). In contrast, there were significantly worse outcomes when ELD livers were used in nonpreferred recipients (3‐year graft survival: ELD 50%, ALD 71%, ILD 75%, P < 0.001; 3‐year patient survival: ELD 64%, ALD 77%, ILD 80%, P < 0.001). Conclusion: The risks of ELDs can be substantially minimized by appropriate recipient selection. (HEPATOLOGY 2007.)This publication has 30 references indexed in Scilit:
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