Reinforcing and Subjective Effects of Methylphenidate: Dose and Time in Bed.
- 1 August 2004
- journal article
- clinical trial
- Published by American Psychological Association (APA) in Experimental and Clinical Psychopharmacology
- Vol. 12 (3), 180-189
- https://doi.org/10.1037/1064-1297.12.3.180
Abstract
So that reinforcing and subjective effects of methylphenidate as a function of dose and level of sleepiness could be evaluated, 21 volunteers received methylphenidate (5, 10, or 20 mg) or placebo on 2 sampling days. After 4 and 8 hr time in bed (TIB), they chose their preferred capsule on 5 days. Methylphenidate was chosen more frequently after 4 hr TIB (60%) than it was after 8 hr TIB (33%). The strongest preference (68%) was seen in the 10-mg group. At 10 and 20 mg, stimulant-like subjective effects were reported. The 10-mg group was more adversely affected by the restricted bedtime and showed more pronounced drug effects with methylphenidate. These results indicate that sleepiness modulates the reinforcing and subjective effects of methylphenidate.Keywords
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