Nephrogenic Systemic Fibrosis
Open Access
- 1 March 2007
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Journal of the American Society of Nephrology
- Vol. 2 (2), 258-263
- https://doi.org/10.2215/cjn.03250906
Abstract
Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis (NSF) is an emerging scleromyxedema-like cutaneous disorder of unknown cause that is seen in patients with renal failure, and the number of reported cases has grown significantly since its first recognition. Recent case reports associated the use of gadolinium (Gd3+)-based contrast agents with the development of NSF. Herein is reported an additional patient who had NSF and had multiple previous exposures to Gd3+-based magnetic resonance imaging studies and had marked improvement in pain and skin changes after a trial of intravenous sodium thiosulfate. Discussed are the possible association of Gd3+-based contrast media with the development of NSF and potential for the use of sodium thiosulfate in the treatment of NSF.Keywords
This publication has 21 references indexed in Scilit:
- Gadolinium deposition in nephrogenic fibrosing dermopathyJournal of the American Academy of Dermatology, 2007
- Gadolinium is detectable within the tissue of patients with nephrogenic systemic fibrosisJournal of the American Academy of Dermatology, 2007
- Nephrogenic Systemic FibrosisJournal of the American Society of Nephrology, 2006
- Description of 12 Cases of Nephrogenic Fibrosing Dermopathy and Review of the LiteratureSeminars in Arthritis and Rheumatism, 2006
- Gadolinium – a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?Nephrology Dialysis Transplantation, 2006
- Nephrogenic Fibrosing Dermopathy With Systemic InvolvementArchives of Dermatology, 2003
- Safety of intravenous gadolinium (Gd-BOPTA) infusion in patients with renal insufficiencyAmerican Journal of Kidney Diseases, 2000
- Scleromyxoedema-like cutaneous diseases in renal-dialysis patientsThe Lancet, 2000
- Safety of approved MR contrast media for intravenous injectionJournal of Magnetic Resonance Imaging, 2000
- Pharmacokinetics of gadodiamide injection in patients with severe renal insufficiency and patients undergoing hemodialysis or continuous ambulatory peritoneal dialysisAcademic Radiology, 1998