Autonomic dysfunction in Parkinson's disease, tested with a computerized method using a Finapres device
- 1 April 1995
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Clinical Autonomic Research
- Vol. 5 (2), 85-89
- https://doi.org/10.1007/bf01827468
Abstract
An automated program using a Finapres device and a personal computer, using a battery of five cardiovascular reflex tests has been developed. This has been used to study cardiovascular autonomic dysfunction in 23 ambulant patients with Parkinson's disease, without disabling fluctuations, and 23 age-matched healthy controls, as a screening method to detect autonomic dysfunction. In one patient only a Finapres signal of insufficient quality due to the tremor excluded subsequent analysis. Heart rate response to forced breathing was abnormal (below the fifth percentile of 124 normals) in six (26.1%) of parkinsonian patients and in one (4.3%) healthy age- and sex-matched control, to standing up four (17.4%) versus none, and to the Valsalva manoeuvre seven (30.4%) versus two (8.7%) respectively. The blood pressure response to standing up was abnormal in two (8.7%) parkinsonian patients and in none of the controls, while the response to sustained handgrip was abnormal in five (21.7%) patients versus one (4.3%) control. Autonomic dysfunction is commonly defined as an abnormal score on two or more of the five tests. Using this arbitrary definition, five patients with Parkinson's disease (=23%) had cardiovascular autonomic dysfunction, and none of the controls were abnormal.Keywords
This publication has 25 references indexed in Scilit:
- Autonomic cardiovascular responses in parkinsonism: effect of levodopa with dopa-decarboxylase inhibitionActa Neurologica Scandinavica, 2009
- Autonomic nervous system dysfunction in Parkinson's disease: relationships with age, medication, duration, and severity.Journal of Neurology, Neurosurgery & Psychiatry, 1993
- Autonomic Functions in the Early Stages of Parkinson's DiseaseInternational Journal of Neuroscience, 1992
- Multiple system atrophy--the nature of the beast.Journal of Neurology, Neurosurgery & Psychiatry, 1989
- The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.Journal of Neurology, Neurosurgery & Psychiatry, 1988
- Evaluation of the Penàz servo-plethysmo-manometer for the continuous, non-invasive measurement of finger blood pressureBasic Research in Cardiology, 1984
- Diagnosis and management of diabetic autonomic neuropathy.BMJ, 1982
- ORTHOSTATIC HYPOTENSION IN PARKINSON'S DISEASEThe Lancet, 1972
- ParkinsonismNeurology, 1967
- A simple test of cardiac function based upon the heart rate changes induced by the valsalva maneuverThe American Journal of Cardiology, 1966