Assessment of atopic eczema: clinical scoring and noninvasive measurements
- 1 October 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 157 (4), 674-680
- https://doi.org/10.1111/j.1365-2133.2007.08101.x
Abstract
Clinical scoring systems are widely used in clinical trials of atopic eczema (AE), while noninvasive methods are more often used for research purposes. Positive correlations between the two types of methods may be used in support of the validity of both in a clinical context. Few studies are available of the association between clinical scores and instrumental assessment of disease severity obtained with noninvasive instruments. To compare clinical scores in AE with biometric data in AE. Transepidermal water loss, stratum corneum hydration, erythema, scaling and subepidermal oedema were measured. 'Scoring of Atopic Dermatitis (SCORAD)', 'Eczema Area and Severity Index (EASI)' and 'Atopic Dermatitis Severity Index (ADSI)' were used for clinical scores. Two assessments at 6-month intervals at the antecubital fossa, dorsal forearm and popliteal fossa in 101 patients with AE and 30 controls were carried out. Significant correlations were found within the clinical scores (P < 0.0001 and r = 0.85-0.91) and between instruments and clinical scores (P < 0.0001 and r = 0.61-0.79). The various instruments and clinical scores showed internal agreement and noninvasive methods correlated significantly with the three different clinical scorings systems. This observation suggests that both methods provide data of clinical (scores) and biological (instrumental measures) relevance, and may be useful in future studies of AE. It is speculated that combined measures including scores and selected instruments may be particularly useful.This publication has 42 references indexed in Scilit:
- Instrumental assessment of atopic eczema: Validation of transepidermal water loss, stratum corneum hydration, erythema, scaling, and edemaJournal of the American Academy of Dermatology, 2006
- Use of the Self-Administered Eczema Area and Severity Index by parent caregivers: results of a validation studyBritish Journal of Dermatology, 2002
- Assessment of ‘Dry Skin’: Current Bioengineering Methodsa nd Test DesignsSkin Pharmacology and Physiology, 2001
- The Inherent Capacitance of Moisturising Creams: A Source of False Positive Results?Skin Pharmacology and Physiology, 2000
- Measurement of body surface area involvement in atopic eczema: an impossible task?British Journal of Dermatology, 1999
- Severity scoring of atopic dermatitis: a comparison of three scoring systemsAllergy, 1997
- Measurement of disease activity and outcome in atopic dermatitisBritish Journal of Dermatology, 1996
- Six Area, Six Sign Atopic Dermatitis (SASSAD) severity score: a simple system for monitoring disease activity in atopic dermatitis*British Journal of Dermatology, 1996
- Levels of Soluble ICAM-1 Are Slightly Elevated in the Serum of Patients with Atopic DermatitisInternational Archives of Allergy and Immunology, 1996
- EEMCO guidance for the assessment of dry skin (xerosis) and ichthyosis: clinical scoring systemsSkin Research and Technology, 1995