Molecular cloning of human prostate specific antigen cDNA
- 20 April 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 214 (2), 317-322
- https://doi.org/10.1016/0014-5793(87)80078-9
Abstract
A λgt11 clone encoding prostate specific antigen has been isolated from a human prostate cDNA library. The cDNA insert of 1415 nucleotides hybridizes specifically to a prostate mRNA species of 1.5 kb. The nucleotide sequence codes for part of a signal peptide, a short propiece and the mature protein of 237 amino acid residues. The M r for the non-glycosylated protein was 26 089. One potential site for N-linked carbohydrate attachment was identified. The primary structure shows extensive homology with proteases of the kallikrein family.Keywords
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