A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury
Top Cited Papers
- 1 August 2011
- journal article
- review article
- Published by Mary Ann Liebert Inc in Journal of Neurotrauma
- Vol. 28 (8), 1611-1682
- https://doi.org/10.1089/neu.2009.1177
Abstract
Cell transplantation therapies have become a major focus in pre-clinical research as a promising strategy for the treatment of spinal cord injury (SCI). In this article, we systematically review the available pre-clinical literature on the most commonly used cell types in order to assess the body of evidence that may support their translation to human SCI patients. These cell types include Schwann cells, olfactory ensheathing glial cells, embryonic and adult neural stem/progenitor cells, fate-restricted neural/glial precursor cells, and bone-marrow stromal cells. Studies were included for review only if they described the transplantation of the cell substrate into an in-vivo model of traumatic SCI, induced either bluntly or sharply. Using these inclusion criteria, 162 studies were identified and reviewed in detail, emphasizing their behavioral effects (although not limiting the scope of the discussion to behavioral effects alone). Significant differences between cells of the same “type” exist based on the species and age of donor, as well as culture conditions and mode of delivery. Many of these studies used cell transplantations in combination with other strategies. The systematic review makes it very apparent that cells derived from rodent sources have been the most extensively studied, while only 19 studies reported the transplantation of human cells, nine of which utilized bone-marrow stromal cells. Similarly, the vast majority of studies have been conducted in rodent models of injury, and few studies have investigated cell transplantation in larger mammals or primates. With respect to the timing of intervention, nearly all of the studies reviewed were conducted with transplantations occurring subacutely and acutely, while chronic treatments were rare and often failed to yield functional benefits.Keywords
This publication has 179 references indexed in Scilit:
- Olfactory Mucosal Autografts and Rehabilitation for Chronic Traumatic Spinal Cord InjuryNeurorehabilitation and Neural Repair, 2009
- OEG implantation and step training enhance hindlimb-stepping ability in adult spinal transected ratsBrain, 2007
- Adenovirus vector-mediated ex vivo gene transfer of brain-derived neurotrophic factor to bone marrow stromal cells promotes axonal regeneration after transplantation in completely transected adult rat spinal cordEuropean Spine Journal, 2007
- Transduced Schwann cells promote axon growth and myelination after spinal cord injuryExperimental Neurology, 2007
- Mesenchymal Stem Cells from Rat Bone Marrow Downregulate Caspase-3-mediated Apoptotic Pathway After Spinal Cord Injury in RatsNeurochemical Research, 2007
- Application of autologous bone marrow stem cells in the therapy of spinal cord injury patientsBulletin of Experimental Biology and Medicine, 2007
- Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injuryProceedings of the National Academy of Sciences of the United States of America, 2006
- Transplantation of Schwann cells to subarachnoid space induces repair in contused rat spinal cordNeuroscience Letters, 2006
- Bone marrow stromal cells can achieve cure of chronic paraplegic rats: Functional and morphological outcome one year after transplantationNeuroscience Letters, 2006
- Detection of 111In-oxine-labeled bone marrow stromal cells after intravenous or intralesional administration in chronic paraplegic ratsNeuroscience Letters, 2005