Effect of Senescence on Macrophage Polarization and Angiogenesis
- 1 February 2008
- journal article
- review article
- Published by Mary Ann Liebert Inc in Rejuvenation Research
- Vol. 11 (1), 177-185
- https://doi.org/10.1089/rej.2007.0614
Abstract
There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.Keywords
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