X linked neonatal myotubular myopathy: one recombination detected with four polymorphic DNA markers from Xq28.
Open Access
- 1 May 1990
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 27 (5), 288-291
- https://doi.org/10.1136/jmg.27.5.288
Abstract
A three generation family with X linked myotubular myopathy (MTM1) was studied with several polymorphic markers from the distal long arm of the X chromosome. A recombination between the disease gene and four markers (loci DXS52, DXS134, DXS15, F8C) from the Xq28 cluster was detected. A new polymorphic marker (U6.2) defining the locus DXS304 in the Xq27-28 region proximal to the Xq28 cluster did not show any recombination with MTM1. These results suggest the following order of loci in distal Xq: cen-DXS42-DXS105-(DXS304, MTM1)-(DXS52, DXS134, DXS15, F8C)-tel.This publication has 3 references indexed in Scilit:
- Isolation of a DNA probe of potential use for diagnosis of the fragile-X syndromeHuman Genetics, 1989
- Morphologic and morphometric analysis of muscle in X-linked myotubular myopathyHuman Pathology, 1986
- X-Linked Neonatal Myotubular MyopathySouthern Medical Journal, 1984