Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity
Open Access
- 9 September 2010
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 47 (1), 370-372
- https://doi.org/10.1039/c0cc02316g
Abstract
We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration.Keywords
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