Effect of Obesity on Oocyte and Embryo Quality in Women Undergoing In Vitro Fertilization
- 1 July 2011
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Obstetrics & Gynecology
- Vol. 118 (1), 63-70
- https://doi.org/10.1097/aog.0b013e31821fd360
Abstract
To estimate the effect of body mass index (BMI) on oocyte and embryo parameters and cycle outcomes in women undergoing in vitro fertilization (IVF). We evaluated a retrospective cohort of 1,721 women undergoing a first IVF cycle with fresh, autologous embryos between 2007 and 2010 in an academic infertility practice. Main outcome measures included number of mature and normally fertilized oocytes, embryo morphology, estradiol on the day of human chorionic gonadotropin administration, clinical pregnancy, spontaneous abortion, and live birth. We performed multivariable analyses, adjusting for potential confounders, including age at cycle start, infertility diagnosis, type of stimulation, total gonadotropin dose, use of intracytoplasmic sperm injection, and number of embryos transferred. Compared with women of normal BMI, women with class II (BMI 35-39.9) and III (BMI 40 or higher) obesity had fewer normally fertilized oocytes (9.3 compared with 7.6 and 7.7, P<.03) and lower estradiol levels (2,047 pg/mL compared with 1,498 and 1,361, P<.001) adjusting for age and despite similar numbers of mature oocytes. Odds of clinical pregnancy (odds ratio [OR] 0.50, 95% confidence interval [CI] 0.31-0.82) and live birth (OR 0.51, 95% CI 0.29-0.87) were 50% lower in women with class III obesity as compared with women of normal BMI. Obesity was associated with fewer normally fertilized oocytes, lower estradiol levels, and lower pregnancy and live birth rates. Infertile women requiring IVF should be encouraged to maintain a normal weight during treatment.Keywords
This publication has 32 references indexed in Scilit:
- Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth ratesHuman Reproduction, 2010
- The great weight debate: do elevations in body mass index (BMI) exert a negative extraovarian effect on in vitro fertilization outcome?Fertility and Sterility, 2008
- Risk factors associated with pregnancies containing a monochorionic pair following assisted reproductive technologiesHuman Reproduction, 2008
- Obesity and poor reproductive outcome: the potential role of the endometriumFertility and Sterility, 2007
- Effect of overweight and obesity on assisted reproductive technology—a systematic reviewHuman Reproduction Update, 2007
- Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donationFertility and Sterility, 2005
- Prevalence of Overweight and Obesity Among US Children, Adolescents, and Adults, 1999-2002Published by American Medical Association (AMA) ,2004
- Body mass index and uterine receptivity in the oocyte donation modelFertility and Sterility, 2003
- Obesity and reproductive disorders in womenHuman Reproduction Update, 2003
- Obesity and the risk of spontaneous abortion after oocyte donationFertility and Sterility, 2003