A distinct influenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia
Open Access
- 1 January 2012
- journal article
- Published by Springer Science and Business Media LLC in Critical Care
- Vol. 16 (4), R157
- https://doi.org/10.1186/cc11477
Abstract
Diagnosis of severe influenza pneumonia remains challenging because of a lack of correlation between the presence of influenza virus and clinical status. We conducted gene-expression profiling in the whole blood of critically ill patients to identify a gene signature that would allow clinicians to distinguish influenza infection from other causes of severe respiratory failure, such as bacterial pneumonia, and noninfective systemic inflammatory response syndrome.Keywords
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