Antiproliferative activity and synthesis of 8-prenylnaringenin derivatives by demethylation of 7-O- and 4′-O-substituted isoxanthohumols
Open Access
- 7 January 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Medicinal Chemistry Research
- Vol. 21 (12), 4230-4238
- https://doi.org/10.1007/s00044-011-9967-8
Abstract
Several analogues of 7-O- and 4′-O-substituted isoxanthohumol and 8-prenylnaringenin, the strongest known phytoestrogen and potential anticancerogenic agent, were synthesized. Acyl, alkyl, and allyl derivatives of isoxanthohumol underwent the demethylation process using MgI2 × 2Et2O in anhydrous THF with the yields of 61–89%. Some of the compounds approached the international criteria of antiproliferative activity (4 μg/ml) for synthetic agents against the human cancer cell lines.Keywords
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