RNA FOLDING DURING TRANSCRIPTION
- 1 June 2006
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biophysics and Biophysical Chemistry
- Vol. 35 (1), 161-175
- https://doi.org/10.1146/annurev.biophys.35.040405.102053
Abstract
The evolution of RNA sequence needs to satisfy three requirements: folding, structure, and function. Studies on folding during transcription are related directly to folding in the cell. Understanding RNA folding during transcription requires the elucidation of structure formation and structural changes of the RNA, and the consideration of intrinsic properties of the RNA polymerase and other proteins that interact with the RNA. This review summarizes the research progress in this area and outlines the enormous challenges facing this field. Significant advancement requires the development of new experimental methods and theoretical considerations in all aspects of transcription and RNA folding.Keywords
This publication has 65 references indexed in Scilit:
- All-atom Monte Carlo Simulation of GCAA RNA FoldingJournal of Molecular Biology, 2004
- Autocatalytic RNA cleavage in the human β-globin pre-mRNA promotes transcription terminationNature, 2004
- Does Native State Topology Determine the RNA Folding Mechanism?Journal of Molecular Biology, 2004
- Regulation by transcription attenuation in bacteria: how RNA provides instructions for transcription termination/antitermination decisionsBioEssays, 2002
- The linkage between magnesium binding and RNA folding 1 1Edited by B. HonigJournal of Molecular Biology, 2002
- RNA simulations: probing hairpin unfolding and the dynamics of a GNRA tetraloop 1 1Edited by J. DovdnaJournal of Molecular Biology, 2002
- Single-Molecule Study of Transcriptional Pausing and Arrest by E. coli RNA PolymeraseScience, 2000
- Facilitation of Group I Splicing in Vivo: Misfolding of the Tetrahymena IVS and the Role of Ribosomal RNA ExonsJournal of Molecular Biology, 1999
- Pathway modulation, circular permutation and rapid RNA folding under kinetic controlJournal of Molecular Biology, 1999
- RNA Polymerase Slides Home: Pause and Termination Site RecognitionCell, 1997