Magnetic Resonance Imaging of Regional Hemodynamic and Cerebrovascular Recovery after Lateral Fluid-Percussion Brain Injury in Rats
Open Access
- 19 May 2010
- journal article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 31 (1), 166-177
- https://doi.org/10.1038/jcbfm.2010.67
Abstract
Hemodynamic and cerebrovascular factors are crucially involved in secondary damage after traumatic brain injury (TBI). With magnetic resonance imaging, this study aimed to quantify regional cerebral blood flow (CBF) by arterial spin labeling and cerebral blood volume by using an intravascular contrast agent, during 14 days after lateral fluid-percussion injury (LFPI) in rats. Immunohistochemical analysis of vessel density was used to evaluate the contribution of vascular damage. Results show widespread ipsilateral and contralateral hypoperfusion, including both the cortex and the hippocampus bilaterally, as well as the ipsilateral thalamus. Hemodynamic unrest may partly be explained by an increase in blood vessel density over a period of 2 weeks in the ipsilateral hippocampus and perilesional cortex. Furthermore, three phases of perilesional alterations in CBF, progressing from hypoperfusion to normal and back to hypoperfusion within 2 weeks were shown for the first time in a rat TBI model. These three phases were similar to hemodynamic fluctuations reported in TBI patients. This makes it feasible to use LFPI in rats to study mechanisms behind hemodynamic changes and to explore novel therapeutic approaches for secondary brain damage after TBI.Keywords
This publication has 46 references indexed in Scilit:
- Perfusional Deficit and the Dynamics of Cerebral Edemas in Experimental Traumatic Brain Injury Using Perfusion and Diffusion-Weighted Magnetic Resonance ImagingJournal of Neurotrauma, 2007
- A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in ratsNeuroscience, 2006
- Animal Models of Post-Traumatic EpilepsyJournal of Neurotrauma, 2006
- Traumatic Cerebral Vascular Injury: The Effects of Concussive Brain Injury on the Cerebral VasculatureJournal of Neurotrauma, 2003
- Uncoupling of Cerebral Blood Flow and Metabolism after Cerebral Contusion in the RatJournal of Cerebral Blood Flow & Metabolism, 2001
- Fluid percussion brain injury in the developing and adult rat: a comparative study of mortality, morphology, intracranial pressure and mean arterial blood pressureDevelopmental Brain Research, 1996
- The Neurochemical and Metabolic Cascade Following Brain Injury: Moving from Animal Models to ManJournal of Neurotrauma, 1995
- Reactive microglia in cerebral ischaemia: an early mediator of tissue damage?Neuropathology and Applied Neurobiology, 1995
- Continuous Monitoring of Posttraumatic Cerebral Blood Flow Using Laser-Doppler FlowmetryJournal of Neurotrauma, 1992
- The Effect of Hypoxia on Traumatic Head Injury in Rats: Alterations in Neurologic Function, Brain Edema, and Cerebral Blood FlowJournal of Cerebral Blood Flow & Metabolism, 1987