Obesity in Cancer Survival
- 31 December 2011
- journal article
- review article
- Published by Annual Reviews in Annual Review of Nutrition
- Vol. 32 (1), 311-342
- https://doi.org/10.1146/annurev-nutr-071811-150713
Abstract
Although obesity is a well-known risk factor for several cancers, its role on cancer survival is poorly understood. We conducted a systematic literature review to assess the current evidence evaluating the impact of body adiposity on the prognosis of the three most common obesity-related cancers: prostate, colorectal, and breast. We included 33 studies of breast cancer, six studies of prostate cancer, and eight studies of colorectal cancer. We note that the evidence overrepresents breast cancer survivorship research and is sparse for prostate and colorectal cancers. Overall, most studies support a relationship between body adiposity and site-specific mortality or cancer progression. However, most of the research was not specifically designed to study these outcomes and, therefore, several methodological issues should be considered before integrating their results to draw conclusions. Further research is urgently warranted to assess the long-term impact of obesity among the growing population of cancer survivors.Keywords
This publication has 111 references indexed in Scilit:
- The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literatureBritish Journal of Cancer, 2011
- A natural history of weight change in men with prostate cancer on androgen-deprivation therapy (ADT): results from the Shared Equal Access Regional Cancer Hospital (SEARCH) databaseBJU International, 2010
- Associations between lifestyle factors and quality of life among older long‐term breast, prostate, and colorectal cancer survivorsCancer, 2009
- Body Mass Index Before and After Breast Cancer Diagnosis: Associations with All-Cause, Breast Cancer, and Cardiovascular Disease MortalityCancer Epidemiology, Biomarkers & Prevention, 2009
- Obesity and poor breast cancer prognosis: an illusion because of hormone replacement therapy?British Journal of Cancer, 2009
- Physical activity and obesity in endometrial cancer survivors: associations with pain, fatigue, and physical functioningAmerican Journal of Obstetrics and Gynecology, 2009
- Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysisThe Lancet Oncology, 2008
- Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancerCancer Causes & Control, 2008
- Obesity and mortality in men with locally advanced prostate cancerCancer, 2007
- Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancerBreast Cancer Research and Treatment, 2006