β-Cyclodextrin catalysed synthesis of tryptanthrin in water
- 2 December 2010
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Green Chemistry
- Vol. 13 (1), 51-54
- https://doi.org/10.1039/c0gc00523a
Abstract
An efficient and green method has been developed for the synthesis of tryptanthrin employing β-cyclodextrin as a catalyst in aqueous media at room temperature from isatoic anhydride and isatin. The reactions were performed under mild conditions to afford biologically active natural product tryptanthrin in excellent yields.This publication has 17 references indexed in Scilit:
- Halogenation reactions in biodegradable solvent: Efficient bromination of substituted 1-aminoanthra-9,10-quinone in deep eutectic solvent (choline chloride : urea)Green Chemistry, 2010
- Isolation, Structure Elucidation, and Synthesis of Cytotoxic Tryptanthrin Analogues from Phaius mishmensisJournal of Natural Products, 2008
- Supramolecular Chemistry of Cyclodextrins in Enzyme TechnologyChemical Reviews, 2007
- Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cellsBiochemical and Biophysical Research Communications, 2007
- Radical reactions with 3H-quinazolin-4-ones: synthesis of deoxyvasicinone, mackinazolinone, luotonin A, rutaecarpine and tryptanthrinOrganic & Biomolecular Chemistry, 2006
- Cyclodextrins as Supramolecular Hosts for Organometallic ComplexesChemical Reviews, 2006
- A facile synthesis of simple alkaloids—synthesis of 2,3-polymethylene-4(3H)-quinazolinones and related alkaloidsTetrahedron Letters, 2003
- Synthesis and Cytotoxic Activity of Conjugates of Muramyl and Normuramyl Dipeptides with Batracylin DerivativesJournal of Medicinal Chemistry, 2003
- Cyclic GMP Phosphodiesterase Inhibitors. 2. Requirement of 6-Substitution of Quinazoline Derivatives for Potent and Selective Inhibitory ActivityJournal of Medicinal Chemistry, 1994
- Antimicrobial Agents from Higher Plants. New Synthesis and Bioactivity of Tryptanthrin(Indolo-[2,1-b]quinazolin-6,12-dione) and Its AnaloguesHETEROCYCLES, 1981