New sequence variants associated with bone mineral density
- 14 December 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 41 (1), 15-17
- https://doi.org/10.1038/ng.284
Abstract
In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.Keywords
This publication has 16 references indexed in Scilit:
- Impact of Genetics on Low Bone Mass in AdultsJournal of Bone and Mineral Research, 2008
- Multiple Genetic Loci for Bone Mineral Density and FracturesNew England Journal of Medicine, 2008
- Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association studyThe Lancet, 2008
- Genetic Analyses in a Sample of Individuals With High or Low BMD Shows Association With Multiple Wnt Pathway GenesJournal of Bone and Mineral Research, 2008
- Large-Scale Analysis of Association Between LRP5 and LRP6 Variants and OsteoporosisJAMA, 2008
- A second generation human haplotype map of over 3.1 million SNPsNature, 2007
- Polymorphisms in the Sclerosteosis/van Buchem Disease Gene (SOST) Region Are Associated with Bone-Mineral Density in Elderly WhitesAmerican Journal of Human Genetics, 2004
- Genetics of OsteoporosisEndocrine Reviews, 2002
- Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem diseaseJournal of Medical Genetics, 2002
- Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)Human Molecular Genetics, 2001