Verification of a two-layer inverse Monte Carlo absorption model using multiple source-detector separation diffuse reflectance spectroscopy
- 2 December 2013
- journal article
- Published by Optica Publishing Group in Biomedical Optics Express
- Vol. 5 (1), 40-53
- https://doi.org/10.1364/boe.5.000040
Abstract
A two-layer Monte Carlo lookup table-based inverse model is validated with two-layered phantoms across physiologically relevant optical property ranges. Reflectance data for source-detector separations of 370 μm and 740 μm were collected from these two-layered phantoms and top layer thickness, reduced scattering coefficient and the top and bottom layer absorption coefficients were extracted using the inverse model and compared to the known values. The results of the phantom verification show that this method is able to accurately extract top layer thickness and scattering when the top layer thickness ranges from 0 to 550 μm. In this range, top layer thicknesses were measured with an average error of 10% and the reduced scattering coefficient was measured with an average error of 15%. The accuracy of top and bottom layer absorption coefficient measurements was found to be highly dependent on top layer thickness, which agrees with physical expectation; however, within appropriate thickness ranges, the error for absorption properties varies from 12-25%.Keywords
Funding Information
- National Institutes of Health (NIH) (NIH R01CA132032, NIH R21EB015892)
- National Science Foundation (NSF) (NSF (DGE-1110007))
This publication has 33 references indexed in Scilit:
- Performance of a lookup table-based approach for measuring tissue optical properties with diffuse optical spectroscopyJournal of Biomedical Optics, 2012
- Quantification of the optical properties of two-layered turbid media by simultaneously analyzing the spectral and spatial information of steady-state diffuse reflectance spectroscopyBiomedical Optics Express, 2011
- Pilot Clinical Study for Quantitative Spectral Diagnosis of Non-Melanoma Skin CancerLasers in Surgery and Medicine, 2010
- Diagnostics of pigmented skin tumors based on laser-induced autofluorescence and diffuse reflectance spectroscopyQuantum Electronics, 2008
- Comparison of a physical model and principal component analysis for the diagnosis of epithelial neoplasias in vivo using diffuse reflectance spectroscopyOptics Express, 2007
- Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue modelJournal of Biomedical Optics, 2007
- Toward the discrimination of early melanoma from common and dysplastic nevus using fiber optic diffuse reflectance spectroscopyJournal of Biomedical Optics, 2005
- Reflectance spectroscopy for in vivo detection of cervical precancerJournal of Biomedical Optics, 2002
- Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissueApplied Optics, 1996
- ANALYTICAL MODELING FOR THE OPTICAL PROPERTIES OF THE SKIN WITH IN VITRO AND IN VIVO APPLICATIONSPhotochemistry and Photobiology, 1981