HIV Treatment as Prevention: Models, Data, and Questions—Towards Evidence-Based Decision-Making
Open Access
- 10 July 2012
- journal article
- review article
- Published by Public Library of Science (PLoS) in PLoS Medicine
- Vol. 9 (7), e1001259
- https://doi.org/10.1371/journal.pmed.1001259
Abstract
Antiretroviral therapy (ART) for those infected with HIV can prevent onward transmission of infection, but biological efficacy alone is not enough to guide policy decisions about the role of ART in reducing HIV incidence. Epidemiology, economics, demography, statistics, biology, and mathematical modelling will be central in framing key decisions in the optimal use of ART. PLoS Medicine, with the HIV Modelling Consortium, has commissioned a set of articles that examine different aspects of HIV treatment as prevention with a forward-looking research agenda. Interlocking themes across these articles are discussed in this introduction. We hope that this article, and others in the collection, will provide a foundation upon which greater collaborations between disciplines will be formed, and will afford deeper insights into the key factors involved, to help strengthen the support for evidence-based decision-making in HIV prevention.Keywords
This publication has 49 references indexed in Scilit:
- Prevention of HIV-1 Infection with Early Antiretroviral TherapyNew England Journal of Medicine, 2011
- The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling studyThe Lancet, 2011
- Community-based intervention to increase HIV testing and case detection in people aged 16–32 years in Tanzania, Zimbabwe, and Thailand (NIMH Project Accept, HPTN 043): a randomised studyThe Lancet Infectious Diseases, 2011
- Concurrent Partnerships, Acute Infection and HIV Epidemic Dynamics Among Young Adults in ZimbabweAIDS and Behavior, 2010
- Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with MenNew England Journal of Medicine, 2010
- Concurrent Sexual Partnerships and Primary HIV Infection: A Critical InteractionAIDS and Behavior, 2010
- Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based studyThe Lancet, 2010
- Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysisThe Lancet, 2010
- Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in ThailandNew England Journal of Medicine, 2009
- Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical modelThe Lancet, 2009