Cytochrome C-Mediated Apoptosis
- 1 June 2004
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 73 (1), 87-106
- https://doi.org/10.1146/annurev.biochem.73.011303.073706
Abstract
▪ Abstract Apoptosis, or programmed cell death, is involved in development, elimination of damaged cells, and maintenance of cell homeostasis. Deregulation of apoptosis may cause diseases, such as cancers, immune diseases, and neurodegenerative disorders. Apoptosis is executed by a subfamily of cysteine proteases known as caspases. In mammalian cells, a major caspase activation pathway is the cytochrome c-initiated pathway. In this pathway, a variety of apoptotic stimuli cause cytochrome c release from mitochondria, which in turn induces a series of biochemical reactions that result in caspase activation and subsequent cell death. In this review, we focus on the recent progress in understanding the biochemical mechanisms and regulation of the pathway, the roles of the pathway in physiology and disease, and their potential therapeutic values.Keywords
This publication has 101 references indexed in Scilit:
- Nerve Growth Factor (NGF) Down-regulates the Bcl-2 Homology 3 (BH3) Domain-only Protein Bim and Suppresses Its Proapoptotic Activity by PhosphorylationOnline Journal of Public Health Informatics, 2002
- HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis ProteinsOnline Journal of Public Health Informatics, 2002
- Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase InteractionOnline Journal of Public Health Informatics, 2002
- Expression of the Prothymosin-α Gene as a Prognostic Factor in Lung CancerSurgery Today, 2001
- PAL31, a Novel Nuclear Protein, Expressed in the Developing BrainBiochemical and Biophysical Research Communications, 2000
- Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions: NUCLEOTIDE REQUIREMENT AND INHIBITOR PROFILEOnline Journal of Public Health Informatics, 1999
- Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome cCell, 1996
- The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene clusterImmunity, 1994
- Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell deathNature, 1990
- Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocationCell, 1986