Joint Attention and Brain Functional Connectivity in Infants and Toddlers
Open Access
- 7 January 2017
- journal article
- research article
- Published by Oxford University Press (OUP) in Cerebral Cortex
- Vol. 27 (3), 1709-1720
- https://doi.org/10.1093/cercor/bhw403
Abstract
Initiating joint attention (IJA), the behavioral instigation of coordinated focus of 2 people on an object, emerges over the first 2 years of life and supports social-communicative functioning related to the healthy development of aspects of language, empathy, and theory of mind. Deficits in IJA provide strong early indicators for autism spectrum disorder, and therapies targeting joint attention have shown tremendous promise. However, the brain systems underlying IJA in early childhood are poorly understood, due in part to significant methodological challenges in imaging localized brain function that supports social behaviors during the first 2 years of life. Herein, we show that the functional organization of the brain is intimately related to the emergence of IJA using functional connectivity magnetic resonance imaging and dimensional behavioral assessments in a large semilongitudinal cohort of infants and toddlers. In particular, though functional connections spanning the brain are involved in IJA, the strongest brain-behavior associations cluster within connections between a small subset of functional brain networks; namely between the visual network and dorsal attention network and between the visual network and posterior cingulate aspects of the default mode network. These observations mark the earliest known description of how functional brain systems underlie a burgeoning fundamental social behavior, may help improve the design of targeted therapies for neurodevelopmental disorders, and, more generally, elucidate physiological mechanisms essential to healthy social behavior development.Keywords
Funding Information
- National Institutes of Health (K01-MH103594, R01-MH093510, K01-MH101653, P30-NS048056, U54-HD087011)
- National Institute of Child Health & Human Development
- Intellectual and Developmental Disabilities Research Center
- Autism Center of Excellence award (#HD055741)
- McDonnell Center for Systems Neuroscience
- Autism Speaks (#6020)
- Simons Foundation (#140209)
This publication has 76 references indexed in Scilit:
- Longitudinal Follow-Up of Children With Autism Receiving Targeted Interventions on Joint Attention and PlayJournal of the American Academy of Child & Adolescent Psychiatry, 2012
- Spurious but systematic correlations in functional connectivity MRI networks arise from subject motionNeuroImage, 2012
- The influence of head motion on intrinsic functional connectivity MRINeuroImage, 2012
- Functional Network Organization of the Human BrainNeuron, 2011
- Functional connectivity MRI in infants: Exploration of the functional organization of the developing brainNeuroImage, 2011
- Unbiased average age-appropriate atlases for pediatric studiesNeuroImage, 2011
- Infant joint attention, neural networks and social cognitionNeural Networks, 2010
- Brain Mechanisms in Early Language AcquisitionNeuron, 2010
- Defining functional areas in individual human brains using resting functional connectivity MRINeuroImage, 2008
- Maps of random walks on complex networks reveal community structureProceedings of the National Academy of Sciences of the United States of America, 2008