Screening for cognition and behaviour changes in ALS
- 19 June 2013
- journal article
- Published by Informa UK Limited in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Vol. 15 (1-2), 9-14
- https://doi.org/10.3109/21678421.2013.805784
Abstract
This study presents the Edinburgh Cognitive and Behavioural ALS Screen (ECAS), developed for ALS patients with physical disability for use by health care professionals. The screen is designed to detect the specific profile of cognition and behaviour changes in ALS and to differentiate it from other disorders. Forty-eight ALS patients (none with evident dementia), 40 healthy controls and 20 carers were recruited. The ECAS, a 15-20-min screen, includes an ALS-Specific score (executive functions and social cognition; fluency; language); an ALS Non-specific score (memory; visuospatial functions); and a carer behaviour screen of five domains characteristic of frontotemporal dementia (FTD). Data from healthy controls produced abnormality cut-offs of 77/100 ALS-Specific score; 24/36 ALS Non-specific score; 105/136 ECAS Total. Twenty-nine percent of patients showed abnormal ALS-Specific scores, and 6% also showed abnormal ALS Non-specific scores. The most prevalent deficit occurred in language functions (35%) followed by executive functions and fluency (23% each). Forty percent of carers reported behaviour change in at least one domain, while 15% met criteria for possible FTD. In conclusion, the ECAS is an effective within-clinic assessment for ALS that determines the presence, severity and type of cognitive and/or behavioural changes, an essential first step to managing these symptoms.Keywords
This publication has 25 references indexed in Scilit:
- Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutationsBrain, 2012
- Amyotrophic lateral sclerosis and frontotemporal dementia: A behavioural and cognitive continuumAmyotrophic Lateral Sclerosis, 2012
- Evidence of Social Understanding Impairment in Patients with Amyotrophic Lateral SclerosisPLOS ONE, 2011
- Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementiaBrain, 2011
- Neuroanatomical correlates of apathy in ALS using 4 Tesla diffusion tensor MRIAmyotrophic Lateral Sclerosis, 2010
- Kana versus Kanji in Amyotrophic Lateral Sclerosis: A Clinicoradiological Study of Writing ErrorsEuropean Neurology, 2010
- Detecting frontotemporal dysfunction in ALS: Utility of the ALS Cognitive Behavioral Screen (ALS-CBS™)Amyotrophic Lateral Sclerosis, 2009
- Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosisAmyotrophic Lateral Sclerosis, 2009
- Detecting neurobehavioral changes in amyotrophic lateral sclerosisAmyotrophic Lateral Sclerosis, 2007
- A screening assessment of cognitive impairment in patients with ALSAmyotrophic Lateral Sclerosis, 2007