Discovering new treatments for sensitive teeth: the long path from biology to therapy
- 19 September 2007
- journal article
- review article
- Published by Wiley in Journal of Oral Rehabilitation
- Vol. 35 (4), 300-315
- https://doi.org/10.1111/j.1365-2842.2007.01798.x
Abstract
Tooth sensitivity is a common dental pain condition where sufferers experience brief episodes of sharp well-localized pain when their teeth are subjected innocuous stimuli such as cold, air-currents and probing with a metallic instrument. In this review, we will make no attempt to describe all the treatments that have been developed to treat tooth sensitivity. We will review the basic anatomic and physiological mechanisms responsible for sensitivity. The insights into the dental lesions responsible for tooth sensitivity, as well as the physiological processes linking stimuli and pain generation have suggested several treatments and preventive strategies. Unfortunately, many tooth sensitivity treatments fail to perform better than placebos in clinical trials that seek to assess the effect of agents on pain symptoms. In the case of the most commonly used self-applied desensitizing agent, potassium salts, the mechanism of action established by laboratory and animal models may not apply to clinical use. Thus results obtained with laboratory and animal models must be applied with care to clinical use. Clinical literature suggests that tooth sensitivity is the symptomatic manifestation of significant dental problems, such as wear and other forms of non-carious tooth structure loss. These conditions are increasing in frequency as people age, retaining their natural teeth longer. They are frequently the consequences of aggressive oral hygiene practices and diets rich in acids. Treatments directed at the underlying causes rather than the symptoms of tooth sensitivity would hinder the development of these lesions and provide researchers with objective targets for assessing therapeutic efficacy.Keywords
This publication has 93 references indexed in Scilit:
- Effects of Plaque Control on the Patency of Dentinal Tubules: An In Vivo Study in Beagle DogsThe Journal of Periodontology, 2006
- Comparison of Fos Expression Within the Ferret’s Spinal Trigeminal Nuclear Complex Evoked by Electrical or Noxious-Thermal Pulpal StimulationThe Journal of Pain, 2005
- Dentine hypersensitivity: development and evaluation ofamodel in situ to study tubulepatencyJournal of Clinical Periodontology, 2004
- In Vivo Sensitivity of Human Root Dentin to Air Blast and ScratchingThe Journal of Periodontology, 2003
- Dentin Morphology and Permeability After Brushing With Different Toothpastes in the Presence and Absence of Smear LayerThe Journal of Periodontology, 2002
- Topical NSAIDs for Musculoskeletal ConditionsDrugs, 1998
- The enigma of potassium ion in the management of dentine hypersensitivity: is nitric oxide the elusive second messenger?Pain, 1996
- Dentine hypersensitivity. II. Effects produced by the uptake in vitro of toothpastes onto dentineJournal of Oral Rehabilitation, 1989
- Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus CodeineThe Journal of Clinical Pharmacology, 1983