DIFFERENTIAL IN VIVO EFFECTS OF WHOLE CIGARETTE SMOKE EXPOSURE VERSUS CIGARETTE SMOKE EXTRACT ON MOUSE CILIATED TRACHEAL EPITHELIUM
- 1 January 2006
- journal article
- research article
- Published by Informa UK Limited in Experimental Lung Research
- Vol. 32 (3-4), 99-118
- https://doi.org/10.1080/01902140600710546
Abstract
In this study the authors compared the affect of vapor phase cigarette smoke (CS) versus cigarette smoke extract (CSE) on the lungs and upper airway of C57BL/6 mice. The authors found that CSE treatment significantly increased neutrophil influx (P < .001), baseline ciliary beat frequency (CBF) (P < .05), and protein kinase C activity compared to CS and controls. Isoproterenol increased CBF with CS exposure, but decreased CBF with CSE (P < .01). Isoproterenol increased protein kinase A (PKA) activity in all groups except CSE. CSE exposure induced inflammatory cell bronchiolitis. These data indicate that CSE exposure has differential effects on the lungs and tracheal epithelium compared to CS exposure.Keywords
This publication has 58 references indexed in Scilit:
- PGE2 inhibits chondrocyte differentiation through PKA and PKC signalingExperimental Cell Research, 2004
- Desensitization of PKA‐Stimulated Ciliary Beat Frequency in an Ethanol‐Fed Rat Model of Cigarette Smoke ExposureAlcohol: Clinical and Experimental Research, 2004
- Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumoniaEuropean Respiratory Journal, 2004
- Lung Tumor Response in Strain a Mice Exposed to Tobacco Smoke: Some Dose-Effect RelationshipsInhalation Toxicology, 2004
- Osmotic Stimuli Increase Clearance of Mucus in Patients with Mucociliary DysfunctionJournal of Aerosol Medicine, 2002
- Interaction of Protein Kinase C and cAMP-dependent Pathways in the Phosphorylation of the Na,K-ATPaseJournal of Biological Chemistry, 2000
- Acetaldehyde-Stimulated PKC Activity in Airway Epithelial Cells Treated with Smoke Extract from Normal and Smokeless CigarettesProceedings of the Society for Experimental Biology and Medicine, 2000
- Regulation of dynein‐driven motility in cilia and flagellaCell Motility, 1994
- The control of ciliary beat frequencyTrends in Cell Biology, 1993
- Effects of .BETA.-adrenoceptor stimulants on the canine tracheal ciliated cells.The Japanese Journal of Pharmacology, 1981