Present status and future perspectives of intestinal transplantation
Open Access
- 1 May 2008
- journal article
- review article
- Published by Frontiers Media SA in Transplant International
- Vol. 21 (5), 401-414
- https://doi.org/10.1111/j.1432-2277.2008.00637.x
Abstract
Intestinal transplantation (ITx) is the only definitive therapy for irreversible intestinal failure. Owing to the limited short- and long-term graft survival over the years, ITx has been a complementary treatment to home parenteral nutrition. However, the development of intestinal and multivisceral transplantation has been significant over the past 15-20 years owing to the progress in immunosuppressive therapy, refinement of surgical techniques, post-transplant care, intestinal immunology, and immunological as well as anti-infectious monitoring. The improvement of patient- and graft survival over the last few years together with data on the cost effectiveness of ITx, following 2 years after transplantation, may require a redefinition of the indication for ITx.Keywords
This publication has 63 references indexed in Scilit:
- Preservation of the Native Spleen, Duodenum, and Pancreas in Patients With Multivisceral Transplantation: Nomenclature, Dispute of Origin, and Proof of PremiseTransplantation, 2007
- Transplantation of the SpleenAnnals of Surgery, 2007
- Optimal Management of the Post–Intestinal Transplant PatientGastroenterology, 2006
- Intestinal Transplantation for Short Bowel Syndrome and Gastrointestinal Failure: Current Consensus, Rewarding Outcomes, and Practical GuidelinesGastroenterology, 2006
- Cost and Quality of Life After Intestinal TransplantationGastroenterology, 2006
- End‐to‐end portocaval shunt for venous drainage of the native foregut in combined liver–intestinal transplantationPediatric Transplantation, 2005
- 100 Multivisceral Transplants at a Single CenterAnnals of Surgery, 2005
- Graft Versus Host Disease in Intestinal TransplantationAmerican Journal of Transplantation, 2004
- Chronic Renal Failure after Transplantation of a Nonrenal OrganNew England Journal of Medicine, 2003
- Organ graft tolerance: the liver effectThe Lancet, 1994