KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome
Open Access
- 1 December 2011
- journal article
- Published by Springer Science and Business Media LLC in Respiratory Research
- Vol. 12 (1), 32
- https://doi.org/10.1186/1465-9921-12-32
Abstract
Background KL-6 is a mucin-like glycoprotein expressed on the surface of alveolar type II cells. Elevated concentrations of KL-6 in serum and epithelial lining fluid (ELF) in patients with acute respiratory distress syndrome (ARDS) have been previously reported; however, kinetics and prognostic significance of KL-6 have not been extensively studied. This study was conducted to clarify these points in ARDS patients. Methods Thirty-two patients with ARDS who received mechanical ventilation under intubation were studied for 28 days. ELF and blood were obtained from each patient at multiple time points after the diagnosis of ARDS. ELF was collected using a bronchoscopic microsampling procedure, and ELF and serum KL-6 concentrations were measured. Results KL-6 levels in ELF on days 0 to 3 after ARDS diagnosis were significantly higher in nonsurvivors than in survivors, and thereafter, there was no difference in concentrations between the two groups. Serum KL-6 levels did not show statistically significant differences between nonsurvivors and survivors at any time point. When the highest KL-6 levels in ELF and serum sample from each patient were examined, KL-6 levels in both ELF and serum were significantly higher in nonsurvivors than in survivors. The optimal cut-off values were set at 3453 U/mL for ELF and 530 U/mL for serum by receiver operating characteristic (ROC) curve analyses. Patients with KL-6 concentrations in ELF higher than 3453 U/mL or serum concentrations higher than 530 U/mL had significantly lower survival rates up to 90 days after ARDS diagnosis. Conclusions ELF and serum KL-6 concentrations were found to be good indicators of clinical outcome in ARDS patients. Particularly, KL-6 levels in ELF measured during the early period after the diagnosis were useful for predicting prognosis in ARDS patients.This publication has 28 references indexed in Scilit:
- Alveolar Fluid Clearance Is Impaired in the Majority of Patients with Acute Lung Injury and the Acute Respiratory Distress SyndromeAmerican Journal of Respiratory and Critical Care Medicine, 2001
- New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndromeCritical Care Medicine, 2001
- The Acute Respiratory Distress SyndromeThe New England Journal of Medicine, 2000
- Serial Changes in Surfactant-associated Proteins in Lung and Serum before and after Onset of ARDSAmerican Journal of Respiratory and Critical Care Medicine, 1999
- Acid-induced Lung InjuryAmerican Journal of Respiratory and Critical Care Medicine, 1999
- Serum marker KL-6/MUC1 for the diagnosis and management of interstitial pneumonitis.1999
- Pathogenesis of fibrosis in acute lung injuryThe American Journal of Medicine, 1992
- Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin.JCI Insight, 1991
- Intact Epithelial Barrier Function Is Critical for the Resolution of Alveolar Edema in HumansAmerican Review of Respiratory Disease, 1990
- New Serum Indicator of Interstitial Pneumonitis ActivitySocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1989