Membrane fusion
Top Cited Papers
- 3 July 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Structural & Molecular Biology
- Vol. 15 (7), 658-664
- https://doi.org/10.1038/nsmb.1451
Abstract
Subcellular compartmentalization, cell growth, hormone secretion and neurotransmission require rapid, targeted, and regulated membrane fusion. Fusion entails extensive lipid rearrangements by two apposed (docked) membrane vesicles, joining their membrane proteins and lipids and mixing their luminal contents without lysis. Fusion of membranes in the secretory pathway involves Rab GTPases; their bound 'effector' proteins, which mediate downstream steps; SNARE proteins, which can 'snare' each other, in cis (bound to one membrane) or in trans (anchored to apposed membranes); and SNARE-associated proteins (SM proteins; NSF or Sec18p; SNAP or Sec17p; and others) cooperating with specific lipids to catalyze fusion. In contrast, mitochondrial and cell-cell fusion events are regulated by and use distinct catalysts.This publication has 134 references indexed in Scilit:
- Viral membrane fusionNature Structural & Molecular Biology, 2008
- Mechanics of membrane fusionNature Structural & Molecular Biology, 2008
- AFF-1, a FOS-1-Regulated Fusogen, Mediates Fusion of the Anchor Cell in C. elegansDevelopmental Cell, 2007
- Reversible, cooperative reactions of yeast vacuole dockingThe EMBO Journal, 2006
- SNAREs — engines for membrane fusionNature Reviews Molecular Cell Biology, 2006
- Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7pThe EMBO Journal, 2006
- Hemifusion in SNARE-mediated membrane fusionNature Structural & Molecular Biology, 2005
- Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomesNature, 2002
- Crystal Structure of the Vesicular Transport Protein Sec17: Implications for SNAP Function in SNARE Complex DisassemblyMolecular Cell, 1999
- SNAP receptors implicated in vesicle targeting and fusionNature, 1993