The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors
- 1 January 2006
- journal article
- review article
- Published by Informa UK Limited in Drug Metabolism Reviews
- Vol. 38 (1-2), 89-116
- https://doi.org/10.1080/03602530600569877
Abstract
Dehydroepiandrosterone has been thought to have physiological functions other than as an androgen precursor. The previous studies performed have demonstrated a number of biological effects in rodents, such as amelioration of disease in diabetic, chemical carcinogenesis, and obesity models. To date, activation of the peroxisome proliferators activated receptor alpha, pregnane X receptor, and estrogen receptor by DHEA and its metabolites have been demonstrated. Several membrane-associated receptors have also been elucidated leading to additional mechanisms by which DHEA may exert its biological effects. This review will provide an overview of the receptor multiplicity involved in the biological activity of this sterol.Keywords
This publication has 124 references indexed in Scilit:
- Novel type of Gq/11 protein‐coupled neurosteroid receptor sensitive to endocrine disrupting chemicals in mast cell line (RBL‐2H3)British Journal of Pharmacology, 2005
- Different ways to regulate the PPARα stabilityBiochemical and Biophysical Research Communications, 2004
- Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasiaMolecular Carcinogenesis, 2003
- The Nuclear Receptor PXR: A Master Regulator of “Homeland” DefenseCritical Reviews™ in Eukaryotic Gene Expression, 2002
- PPARα Agonists Reduce 11β-Hydroxysteroid Dehydrogenase Type 1 in the LiverBiochemical and Biophysical Research Communications, 2000
- Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.JCI Insight, 1997
- Effects of dehydroepiandrosterone on proliferation of human aortic smooth muscle cellsLife Sciences, 1997
- Cloning of a novel receptor expressed in rat prostate and ovary.Proceedings of the National Academy of Sciences of the United States of America, 1996
- Regulation of Cytochromes P450 by DHEA and Its Anticarcinogenic ActionAnnals of the New York Academy of Sciences, 1995
- A Prospective Study of Dehydroepiandrosterone Sulfate, Mortality, and Cardiovascular DiseaseNew England Journal of Medicine, 1986