bla NDM-5 Carried by an IncX3 Plasmid in Escherichia coli Sequence Type 167
Open Access
- 1 December 2014
- journal article
- case report
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 58 (12), 7548-7552
- https://doi.org/10.1128/aac.03911-14
Abstract
blaNDM-5 was found in Escherichia coli strain 0215 from a Chinese patient without travel history. Genomic sequencing and conjugation experiments were performed. Strain 0215 belonged to sequence type 167 (ST167) and had other resistance determinants, including blaTEM-135, blaCTX-M-14, and aac(6′)-Ib. blaNDM-5 was carried by a 47-kb self-transmissible IncX3 plasmid and was in a complex genetic context similar to that of blaNDM-1 on IncX3 plasmids. IncX3 plasmids might have emerged as a common vehicle mediating the spread of blaNDM.Keywords
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