Cholesterol Accumulation Is Associated with Lysosomal Dysfunction and Autophagic Stress in Npc1−/− Mouse Brain
- 30 September 2007
- journal article
- Published by Elsevier BV in The American Journal of Pathology
- Vol. 171 (3), 962-975
- https://doi.org/10.2353/ajpath.2007.070052
Abstract
No abstract availableKeywords
This publication has 75 references indexed in Scilit:
- Folding, activity and targeting of mutated human cathepsin D that cannot be processed into the double-chain formThe International Journal of Biochemistry & Cell Biology, 2007
- Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceNature, 2006
- Loss of autophagy in the central nervous system causes neurodegeneration in miceNature, 2006
- Deregulation of the Phosphatidylinositol-3 Kinase Signaling Cascade Is Associated with Neurodegeneration in Npc1−/− Mouse BrainThe American Journal of Pathology, 2005
- Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targetingCell Death & Differentiation, 2005
- Cell-Autonomous Death of Cerebellar Purkinje Neurons with Autophagy in Niemann-Pick Type C DiseasePLoS Genetics, 2005
- Niemann-Pick Type C Disease and Intracellular Cholesterol TraffickingJournal of Biological Chemistry, 2005
- The p75 Neurotrophin Receptor Can Induce Autophagy and Death of Cerebellar Purkinje NeuronsJournal of Neuroscience, 2004
- A Novel Protein Complex Linking the δ2 Glutamate Receptor and AutophagyNeuron, 2002
- LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingThe EMBO Journal, 2000