Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1‐13C]pyruvate and 13C magnetic resonance spectroscopic imaging
Open Access
- 16 November 2010
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 65 (2), 557-563
- https://doi.org/10.1002/mrm.22698
Abstract
We show here that hyperpolarized [1‐13C]pyruvate can be used to detect treatment response in a glioma tumor model; a tumor type where detection of response with 18fluoro‐2‐deoxyglucose, using positron emission tomography, is limited by the high background signals from normal brain tissue. 13C chemical shift images acquired following intravenous injection of hyperpolarized [1‐13C]pyruvate into rats with implanted C6 gliomas showed significant labeling of lactate within the tumors but comparatively low levels in surrounding brain.Labeled pyruvate was observed at high levels in blood vessels above the brain and from other major vessels elsewhere but was detected at only low levels in tumor and brain.The ratio of hyperpolarized 13C label in tumor lactate compared to the maximum pyruvate signal in the blood vessels was decreased from 0.38 ± 0.16 to 0.23 ± 0.13, (a reduction of 34%) by 72 h following whole brain irradiation with 15 Gy. Magn Reson Med, 2011.Keywords
Funding Information
- Cancer Research UK Programme Grant (C197/A3514)
- NINDS
- NIH
- NCI
This publication has 23 references indexed in Scilit:
- Metabolic imaging in the anesthetized rat brain using hyperpolarized [1‐13C] pyruvate and [1‐13C] ethyl pyruvateMagnetic Resonance in Medicine, 2010
- Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphomaMagnetic Resonance in Medicine, 2010
- Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumorsNeuro-Oncology, 2010
- Comparison of 18F-FET and 18F-FDG PET in brain tumorsNuclear Medicine and Biology, 2009
- Application of subsecond spiral chemical shift imaging to real‐time multislice metabolic imaging of the rat in vivo after injection of hyperpolarized 13C1‐pyruvateMagnetic Resonance in Medicine, 2009
- Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C‐pyruvateMagnetic Resonance in Medicine, 2009
- Incidence of early pseudo‐progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomideCancer, 2008
- Metabolic Assessment of Gliomas Using11C-Methionine, [18F] Fluorodeoxyglucose, and11C-Choline Positron-Emission TomographyAmerican Journal of Neuroradiology, 2008
- New approaches for imaging tumour responses to treatmentNature Reviews Cancer, 2008
- In vivo imaging of glucose consumption and lactate concentration in human gliomasAnnals of Neurology, 1992