Physical and clinical performance of the mCT time-of-flight PET/CT scanner
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- 22 March 2011
- journal article
- research article
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 56 (8), 2375-2389
- https://doi.org/10.1088/0031-9155/56/8/004
Abstract
Time-of-flight (TOF) measurement capability promises to improve PET image quality. We characterized the physical and clinical PET performance of the first Biograph mCT TOF PET/CT scanner (Siemens Medical Solutions USA, Inc.) in comparison with its predecessor, the Biograph TruePoint TrueV. In particular, we defined the improvements with TOF. The physical performance was evaluated according to the National Electrical Manufacturers Association (NEMA) NU 2-2007 standard with additional measurements to specifically address the TOF capability. Patient data were analyzed to obtain the clinical performance of the scanner. As expected for the same size crystal detectors, a similar spatial resolution was measured on the mCT as on the TruePoint TrueV. The mCT demonstrated modestly higher sensitivity (increase by 19.7 ± 2.8%) and peak noise equivalent count rate (NECR) (increase by 15.5 ± 5.7%) with similar scatter fractions. The energy, time and spatial resolutions for a varying single count rate of up to 55 Mcps resulted in 11.5 ± 0.2% (FWHM), 527.5 ± 4.9 ps (FWHM) and 4.1 ± 0.0 mm (FWHM), respectively. With the addition of TOF, the mCT also produced substantially higher image contrast recovery and signal-to-noise ratios in a clinically-relevant phantom geometry. The benefits of TOF were clearly demonstrated in representative patient images.Keywords
This publication has 8 references indexed in Scilit:
- An Assessment of the Impact of Incorporating Time-of-Flight Information into Clinical PET/CT ImagingJournal of Nuclear Medicine, 2010
- Performance Characteristics of a New LSO PET/CT Scanner With Extended Axial Field-of-View and PSF ReconstructionIEEE Transactions on Nuclear Science, 2009
- Benefit of Time-of-Flight in PET: Experimental and Clinical ResultsJournal of Nuclear Medicine, 2008
- Fully 3-D PET reconstruction with system matrix derived from point source measurementsIEEE Transactions on Medical Imaging, 2006
- Comparison of 3-D reconstruction with 3D-OSEM and with FORE+OSEM for PETIEEE Transactions on Medical Imaging, 2001
- Fast reconstruction of 3D PET data with accurate statistical modelingIEEE Transactions on Nuclear Science, 1998
- Cerium-doped lutetium oxyorthosilicate: a fast, efficient new scintillatorIEEE Transactions on Nuclear Science, 1992
- Instrumentation trends in nuclear medicineSeminars in Nuclear Medicine, 1977