Molecular Epidemiology and Outcome ofHelicobacter pyloriInfection in Thailand: a Cultural Cross Roads
- 1 October 2004
- journal article
- Published by Wiley in Helicobacter
- Vol. 9 (5), 453-459
- https://doi.org/10.1111/j.1083-4389.2004.00260.x
Abstract
Background. Thailand is at the cultural cross roads between East and South Asia. It has been suggested that this is also the region where the predominant Helicobacter pylori (H. pylori) genotype changes from East Asian to South Asian. Methods. We compared the molecular epidemiology and outcome of H. pylori infections among different ethnic groups in Thailand (Thai, Thai‐Chinese and Chinese). H. pylori isolates were genotyped by polymerase chain reaction based on cagA, cag right end junction and vacA genotypes. Results. Ninety‐eight isolates from 38 ethnic Thai, 20 ethnic Chinese and 40 Thai‐Chinese were categorized into East Asian (45%), South/Central Asian (26%), Western (1%) or mixed type (29%). The East Asian genotype was the most common among Chinese (85%) and Thai‐Chinese (55%) (p < .01 compared to ethnic Thai). The ethnicity of the mother among mixed Thai‐Chinese marriages predicted the genotype of the child's H. pylori (e.g. when the mother was Chinese, 84% had East Asian type vs. 29% when the mother was Thai) (p < .001). Gastric cancer was common among ethnic Chinese with East Asian genotype (e.g. all Chinese with gastric cancer or peptic ulcer disease had East Asian genotype, whereas only 40% of Chinese with gastritis had this genotype). Conclusions. Immigration, intermarriage and the variety of H. pylori genotypes in Thailand suggest that Thailand is an ideal site for epidemiological studies attempting to relate H. pylori genotypes and host factors to outcome. Our data also support the hypothesis that the primary caretaker of the children is most likely the source of the infection.Keywords
This publication has 15 references indexed in Scilit:
- Association between Diversity in the Src Homology 2 Domain–Containing Tyrosine Phosphatase Binding Site ofHelicobacter pyloriCagA Protein and Gastric Atrophy and CancerThe Journal of Infectious Diseases, 2004
- Traces of Human Migrations in Helicobacter pylori PopulationsScience, 2003
- East Asian genotypes of Helicobacter pylori strains in Amerindians provide evidence for its ancient human carriageProceedings of the National Academy of Sciences of the United States of America, 2002
- Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sitesProceedings of the National Academy of Sciences of the United States of America, 2002
- Helicobacter pylori in North and South America before ColumbusFEBS Letters, 2002
- Distinctiveness of Genotypes ofHelicobacter pyloriin Calcutta, IndiaJournal of Bacteriology, 2000
- Conservation ofHelicobacter pyloriGenotypes in Different Ethnic Groups in Houston, TexasThe Journal of Infectious Diseases, 2000
- Relationship between the cagA 3' repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pHGastroenterology, 1999
- Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pyloriJournal of Biological Chemistry, 1995
- Dietary salt and gastric ulcer.Gut, 1986