Van Huyssteen’s 2004 Edinburgh Gifford Lectures raise the question of how human uniqueness is to be understood in evolutionary and theological terms. This has been defended in subsequent interaction with critics. In this article, his approach is explored in light of recent challenges to theological anthropocentrism. While a weak or benign form of anthropocentrism can be sustained along the lines mapped out by van Huyssteen, it is argued that this requires some rethinking in relation to the imago Dei and to accounts of incarnation, providence, and eschatology.