Iron(III)-salen complexes with less DNA cleavage activity exhibit more efficient apoptosis in MCF7 cells
- 15 January 2009
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 7 (5), 926-932
- https://doi.org/10.1039/b816858j
Abstract
To understand the relationship between DNA damage potential and biochemical activities, we synthesized nine different Fe(III)-salen derivatives with varying substituents, and analyzed their in vitro DNA cleavage properties and biochemical effects on cultured human cells. Our results demonstrated that Fe(III)-salen complexes affect cell viability, induce nuclear fragmentation, and activate caspases and apoptosis in cultured human cells. The nature and the position of the substituents in the Fe(III)-salen complexes play critical roles in determining their apoptotic efficiencies. Most importantly, our results demonstrated that the in vitro DNA cleavage activities of Fe(III)-salen complexes are not essential for their apoptotic activities in human cells. Instead, the lesser their DNA cleavage activity the greater is their apoptotic efficiency.Keywords
This publication has 40 references indexed in Scilit:
- Iron(III)-salen damages DNA and induces apoptosis in human cell via mitochondrial pathwayJournal of Inorganic Biochemistry, 2008
- Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expressionBiochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2008
- Reductive and Oxidative DNA Damage by Photoactive Platinum(II) IntercalatorsInorganic Chemistry, 2005
- Platinum agents in the treatment of osteosarcoma: Efficacy of cisplatin vs. carboplatin in human osteosarcoma cell linesMedical and Pediatric Oncology, 2002
- Salen−Manganese Complexes as Catalytic Scavengers of Hydrogen Peroxide and Cytoprotective Agents: Structure−Activity Relationship StudiesJournal of Medicinal Chemistry, 2002
- Role of the Central Metal Ion and Ligand Charge in the DNA Binding and Modification by Metallosalen ComplexesBioconjugate Chemistry, 1997
- DNA cleavage by intercalatable cobalt–bispicolylamine complexes activated by visible lightChemical Communications, 1996
- Ambient oxygen activating water soluble cobalt–salen complex for DNA cleavageJournal of the Chemical Society, Chemical Communications, 1995
- Synergetic catalysis by two non-lanthanide metal ions for hydrolysis of diribonucleotidesJournal of the Chemical Society, Chemical Communications, 1995
- Carboplatin in combination as first-line therapy in advanced breast cancerCancer Treatment Reviews, 1993