Pathogenesis and Management of Lipoprotein Disorders

Abstract

Lipoprotein particles transport cholesterol and triglycerides in the bloodstream. Abnormalities of plasma lipoproteins can result in a predisposition to premature coronary artery disease, pancreatitis, or neurologic disease. Recent advances in our understanding of plasma lipoprotein disorders have contributed to better diagnosis and treatment of these diseases and have provided important insights into normal lipoprotein metabolism. Our purpose is to provide a concise overview of the diagnosis, pathogenesis, and management of lipoprotein disorders.Plasma lipoproteins are generally spherical particles with a surface that consists largely of phospholipid, free cholesterol, and protein, and a core that contains mostly triglyceride and cholesterol ester. . . .