Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
- 1 February 1986
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 43 (2), 114-24
- https://doi.org/10.1001/archpsyc.1986.01800020020004
Abstract
To evaluate dorsolateral prefrontal cortex (DLPFC) physiology and function simultaneously, 20 medication-free patients with chronic schizophrenia and 25 normal controls underwent three separate xenon Xe 133 inhalation procedures for determination of regional cerebral blood flow (rCBF): first at rest, then while performing an automated version of the Wisconsin Card Sort (WCS), a DLPFC-specific cognitive test, and while performing a simple number-matching (NM) test. During rest, patients had significantly reduced relative, but not absolute, rCBF to DLPFC. During NM, no specific region differentiated patients from controls. During WCS, however, both absolute and relative rCBF to DLPFC significantly distinguished patients from controls. While controls showed a clear increase in DLPFC rCBF, patients did not. The changes were regionally specific, involving only DLPFC. Furthermore, in patients, DLPFC rCBF correlated positively with WCS cognitive performance, suggesting that the better DLPFC was able to function, the better patients could perform. Autonomic arousal measures, the pattern of WCS errors, and results of complementary studies suggest that the DLPFC finding is linked to regionally specific cognitive function and is not a nonspecific epiphenomenon.Keywords
This publication has 47 references indexed in Scilit:
- Frontal lobe dysfunctions in schizophrenia—II. impairments of psychological and brain functionsJournal of Psychiatric Research, 1984
- Cognitive impairment in schizophreniaAmerican Journal of Psychiatry, 1984
- Performance of Schizophrenic Patients on Tests Sensitive To Left or Right Frontal, Temporal, or Parietal Function in Neurological PatientsJournal of Nervous & Mental Disease, 1983
- CEREBRAL VENTRICULAR SIZE: A BIOLOGICAL MARKER FOR SUB-TYPING CHRONIC SCHIZOPHRENIAPublished by Elsevier BV ,1982
- Eye-Tracking Patterns in SchizophreniaArchives of General Psychiatry, 1981
- Neurologic Soft Signs in Schizophrenia and Character DisordersArchives of General Psychiatry, 1976
- Absence of activation in frontal structures during psychological testing of chronic schizophrenics.Journal of Neurology, Neurosurgery & Psychiatry, 1975
- On Frontal Lobe Functions: Psychiatric Patient ControlsCortex, 1974
- ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIAActa Psychiatrica Scandinavica, 1974
- The Neurology of SchizophreniaJournal of Mental Science, 1956