Prolactin Receptors in Rat Liver: Possible Induction by Prolactin
- 4 April 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 188 (4183), 57-59
- https://doi.org/10.1126/science.163493
Abstract
A prolactin receptor, present in adult female rat liver, can be induced in males by estrogen. Hypophysectomy diminished receptor levels in the female and rendered males unresponsive to estrogen. A renal pituitary implant blunted the decrease in hypophysectomized females and induced the receptor in hyophysectomized males. The increased receptor level in hypophysectomized males with a renal pituitary implant was preceded by a sustained elevation of circulating prolactin. Our observations suggest that prolactin induces its own receptor.Keywords
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